Pair Name	Curcumin, ABT-888
Disease Info	[ICD-11:2B5Y]	Malignant mesenchymal neoplasm		Investigative
Biological Phenomena	Inhibition-->Homologous recombination
Gene Regulation	Up-regulation	Expression	H2AX	hsa3014
	Down-regulation	Expression	RAD51	hsa5888
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	U2OS	Osteosarcoma	Homo sapiens (Human)	CVCL_0042
In Vivo Model	2×10⁶ human MDA-MB-231 cells were prepared with 200 uL of PBS/matrigel gel (1:1 ratio) and injected subcutaneously into the flanks of athymic nude mice (two-site injections).
Result	Our study indicates that cotreatment of curcumin and PARP inhibitor might be useful for the combination chemotherapy for aggressive breast cancer treatment as a natural bioactive compound.